This is the most common cause of nephrotic syndrome in children. Diabetes can lead to kidney damage (diabetic nephropathy) that affects the glomeruli. Many diseases and conditions can cause glomerular damage and lead to nephrotic syndrome, including: When damaged, glomeruli allow too much blood protein to leave your body, leading to nephrotic syndrome. Healthy glomeruli keep blood protein (mainly albumin) - which is needed to maintain the right amount of fluid in your body - from seeping into your urine. The glomeruli filter your blood as it passes through your kidneys, separating things your body needs from those it doesn't. Nephrotic syndrome is usually caused by damage to the clusters of tiny blood vessels (glomeruli) of your kidneys. The condition causes swelling, particularly in your feet and ankles, and increases the risk of other health problems. Nephrotic syndrome is usually caused by damage to the clusters of small blood vessels in your kidneys that filter waste and excess water from your blood. ![]() Nephrotic syndrome is a kidney disorder that causes your body to pass too much protein in your urine. The excess water and waste become urine that flows to the bladder. The water, nutrients and minerals your body needs are transferred back to the bloodstream. The filtered solution then passes into another part of the nephron called the tubule. Large molecules, such as proteins and red blood cells, do not. ![]() When blood flows into a glomerulus, tiny molecules - water, essential minerals and nutrients, and wastes - pass through the capillary walls. Each nephron contains a filter (glomerulus) that has a network of tiny blood vessels called capillaries. The kidneys remove waste and excess fluid from your blood through filtering units called nephrons.
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